Atherosclerosis

We provide a large contract research program on energy metabolism in relation to obesity, type 2 diabetes, NASH and atherosclerosis. Within this field of expertise we offer custom-made drug and dietary intervention studies in our unique APOE*3-Leiden.CETP  mouse model, a well-established model for human-like lipid metabolism and atherosclerosis.

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7 Tesla Achieva Philips whole body MRI

State-of-the-art MRI scanner with ultra-high magnetic field strength (7 Tesla) for increased image quality, contrast and/or resolution. Coils are available for brain (proton, sodium, and phosphorus), knee (proton and sodium), muscle (proton and phosphorus) and cardiac applications. Available scan protocols include SWI, FLAIR, BOLD, TOF, T1, T2, and spectroscopy.

Area/application:
– Neuroimaging, muscle, and cardiac research.
– Anatomical, metabolic and functional imaging
– Brain imaging in diseases like epilepsy, Alzheimer’s Disease, Huntington’s Disease, migraine, etc

EchoMRI-100

Delivers precise and rapid body composition measurements of total fat and lean mass and isolated organs.

Area/Application:
Obesity, metabolic syndrome, dyslipidemia, energy metabolism, brown adipose tissue, diabetes, atherosclerosis, NASH, microbiota.

TSE Phenomaster

State-of-the-art technology for fully automated and perfectly synchronized metabolic, behavioural, and physiological monitoring.

Measurements include indirect gas calorimetry (to estimate various metabolic parameters such as respiratory exchange rate (RER) and energy expenditure (EE)), food and liquid intake, locomotor activity, exercise and more.

Area/Application:
Energy metabolism, brown adipose tissue, obesity, metabolic disease, dyslipidemia, diabetes, atherosclerosis, microbiota, physiology.

 

In vitro evaluation

We have the facilities and expertise to perform in vitro affinity/specificity studies and intracellular distribution studies for compounds with a fluorescent label. These services help provide to take the first step in the preclinical evaluation of new imaging targets/imaging agents. (more…)

Custom synthesis/conjugation

If your product development requires a specific peptide and/or imaging label design, we can explore possible synthetic routes and and can perform custom synthesis. On top we can take care of bioconjugation to peptides, proteins etc. If desired structure activity optimizations can be performed and the synthetic route can be made suitable for cGMP production, which may be facilitated by the GMP production facility at the LUMC. (more…)

Fluorescent dyes and multimodal imaging labels

We have numerous in-house synthesized fluorescent dyes available for conjugation and tailoring of the tracer kinetics. On top we have labels available for conjugation that combine a fluorescent dye with the most routinely used chelates available for SPECT or PET imaging. Please let us know if you have a specific design in mind and we can see if it can be tailor made. (more…)

Interventional Molecular Imaging Lab

The Interventional Molecular Imaging Lab in the Leiden University Medical Center is dedicated to the synthesis and development of radiolabeled and fluorescent peptides, proteins and antibodies with particular expertise in hybrid labelling. We find synthesis solutions to difficult imaging problems. While others can merely synthesize or evaluate a compound, we offer synthesis tailored to the specific requirements of our clients and assist in the evaluation of the labelled compound. We use our clinical experience to arrive at the optimal structure-activity relationship.

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